Case Report
Open Access
The Study of Emergency Laboratory Abnormalities of Poisoning Cases admitted at Narayana medical College and Hospital, Nellore
Kondle Raghu", P. Shreevani', S. Satish Kumar!, Mahaboob Vali Shaik’, Shaik Basha Ahammad
'Department of Emergeny & Critical care Medicine, Narayana Medical College
Hospital Chintareddypalem Nellore -524002, and Andhra Pradesh. India.
Advanced Research Centre, Narayana Medical College Hospital
Chintareddypalem Nellore -524002, and Andhra Pradesh. India.
’Department of Community Medicine, Narayana Medical College Hospital
Chintareddypalem Nellore -524002, and Andhra Pradesh. India.
Kondle Raghu, P. Shreevani, S. Satish Kumar, Mahaboob Vali Shaik, Shaik Basha Ahammad. The Study of Emergency Laboratory Abnormalities of Poisoning Cases admitted at Narayana medical College and Hospital, Nellore. Asian Journal of Pharmacology and Toxicology, 03(12), 2015, 52-55.
Abstract
Aim: This study was designed to evaluate the relationship between
laboratory parameters and the degree of intoxication in patients
attempted to commit suicide using various toxic agents admitted to
the emergency department.
Methods: 537 patients who attempted to suicide during the period
of 4 years between April 2009 and April 2013 admitted to the
emergency department were included in this retrospective study.
Fatal poisonings were studied for socioeconomic status, type of
poison and way of manner (accidental, suicidal or homicidal). The
initial laboratory findings and clinical status of patients were
evaluated. Clinical severity of patients was also graded according to
the Bardin classification on admission.
Results: Oral intake of poison was found to be the most common
route for suicidal purpose. Acute renal failure was observed during
admission in some patients of grade 2 and 3. Cholinesterase activity
was measured significantly depressed in the grade 1, 2 and 3. SGOT,
SGPT and ALP levels were significantly higher in the grade 1 and 2,
but they were considerably elevated in the grade 3 compared to
normal reference.
Conclusions: There is decrease of cholinesterase activity appears to
be associated with clinical severity in acute organophosphate
intoxication. Liver function enzymes were increased in patients of
grade | and 2 renal failure.
Keywords
poisoning, suicide, Organophosphorus, cholinesterase, APACHE score
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