Background: Belonging to flavanone class, pinocembrin (5, 7-dihydroxyflavanone) is a flavonoid abundant in propolis. Pinocembrin was synthesized and approved by the State Food and Drug Administration of China for stroke clinical trials in 2008. In recent years, the biological and pharmacological effects of pinocembrin on systemic functions have attracted attention. Objective: In this paper an overview is given of the biological mechanisms and the pharmacological evidence of pinocembrin on several biological functions.
Methodology: publication records as documented by the authors were reviewed for the study.
Results: The perspectives include antiinflammatory activity, as well as antifeedant, vasorelaxant, neuroprotective, antioxydant, antifungal, apoptosis-inducing activities. Its emerging role as a dominant biomarker for both biological materials has spread considerable interest.
Conclusion: It is cleared that due to its mechanisms, pinocembrin has many important applications in pharmacology and ethnobotany. All these areas that have been identified should form the focus of future researchers working on pinocembrin.